If you use CAPS in your research, please include the following citations: CAPS: coevolution analysis using protein sequences. Fares MA, McNally D. Bioinformatics. 2006 Nov 15;22(22):2821-2. PMID: 17005535 https://www.ncbi.nlm.nih.gov/pubmed/17005535 The mathematical model has been described separately: A novel method for detecting intramolecular coevolution: adding a further dimension to selective constraints analyses. Fares MA, Travers SA. Genetics. 2006 May;173(1):9-23. PMID: 16547113 https://www.ncbi.nlm.nih.gov/pubmed/16547113