A general, minimal Python framework for building hybrid asynchronous decomposition samplers for quadratic unconstrained binary optimization (QUBO) problems. dwave-hybrid facilitates three aspects of solution development: - Hybrid approaches to combining quantum and classical compute resources - Evaluating a portfolio of algorithmic components and problem-decomposition trategies - Experimenting with workflow structures and parameters to obtain the best application results The framework enables rapid development and insight into expected performance of productized versions of its experimental prototypes.