vCAPS: (verbose) Coevolution Analysis using Protein Sequences CAPS is aimed at measuring the coevolution between amino acid sites belonging to the same protein (intra-molecular coevolution) or to two functionally or physically interacting proteins (inter-molecular coevolution). The Software implements an improved method to detect intra-molecular coevolution as published in Genetics (Fares and Travers, 2006) and also inter-protein coevolution analysis. The improved scoring of amino acid sites is obtained by maximum likelihood ancestral state reconstruction along with simulations to assess significance. This is a modified version of "CAPS_coevolution", used in the AutoCoEv pipeline: https://github.com/mattilalab/autocoev It applies two _unofficial_ patches: - 01_caps_verbose: makes the program output its generated trees, as well as the p-value for each correlated amino acid pair - 02_caps_sort_input: introduce a function to sort input file names The produced executable is called "vCAPS" and can be installed along "caps" from CAPS_coevolution. Building CAPS from source requires the Bio++ 1.9 suite libraries, but make sure the current versions of the bppsuite (and its dependencies) are NOT installed at build time. Citing CAPS: CAPS: coevolution analysis using protein sequences. Fares MA, McNally D. Bioinformatics. 2006 Nov 15;22(22):2821-2. PMID: 17005535 The mathematical model has been described separately: A novel method for detecting intramolecular coevolution: adding a further dimension to selective constraints analyses. Fares MA, Travers SA. Genetics. 2006 May;173(1):9-23. PMID: 16547113